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-Garcinia Cambogia Extract - 125mg
-Garcinia Cambogia Extract - 125mg
-Guarana Extract - 125mg
-Fucus Vesiculosus - 200mg
Here below you can find some scientific information that is collected from trusted web sites on net.
GARCINIA
Garcinia cambogia is a small fruit that resembles a miniature pumpkin. It is indigenous to India and parts of Asia, and an extract from its fruit and rind is popular in many natural weight loss products. The extract is hydroxycitric acid (HCA), claimed to suppress appetite and enhance fat-burning. Animal research supports these claims, but subsequent human trials have been equivocal.
The theory behind garcinia cambogia is that HCA inhibits an enzyme called citrate lyase that helps turns excess carbohydrates into fat. By inhibiting this enzyme, it is believed the body instead boosts carbohydrate oxidation, or simply put, burns the extra carbs. In extensive animal studies, garcinia cambogia was found to reduce food intake by suppressing appetite, as well as to decrease body fat. Human trials have been less clear. While some double-blind studies using garcinia cambogia and a placebo showed the HCA group as doubling or tripling weight loss over a 12-week period as compared to the control group, other studies showed a less promising result.
The Journal of the American Medical Association (JAMA) published such a study that used a daily dose of 1500mg of HCA over a 12-week period on healthy, overweight adults. At the end of the study, the group receiving garcinia cambogia did not see statistically different weight loss from the control group. However, this study has been criticized by some, with the claim that the high-fiber diet used in the trial likely interfered with the body’s ability to absorb HCA. Unfortunately, the study did not test the subjects to see whether HCA was found in the cells where it becomes active.
Garcinia cambogia reportedly does not have any known adverse effects in healthy adults, but there are some people who are advised not to take it. According to experts, this includes children, pregnant and lactating women, those diagnosed with diabetes mellitus, and people with Alzheimer’s or other forms of dementia disease. In the case of Alzheimer’s patients, it is thought HCA might form acetylcholine in the brain, while diabetics could be affected by HCA’s tendency to lower blood sugar. Conversely, in healthy adults this latter effect can purportedly curb cravings for sweets and carbohydrates.
Garcinia cambogia is usually sold in capsule form, standardized to include a percentage of HCA, the active ingredient. Only brands standardized to 50% or greater HCA are generally recommended. For maximum effect, the daily dose is divided in three parts, taking one or more capsules 30-60 minutes before breakfast, lunch, and dinner.
The theory behind garcinia cambogia is that HCA inhibits an enzyme called citrate lyase that helps turns excess carbohydrates into fat. By inhibiting this enzyme, it is believed the body instead boosts carbohydrate oxidation, or simply put, burns the extra carbs. In extensive animal studies, garcinia cambogia was found to reduce food intake by suppressing appetite, as well as to decrease body fat. Human trials have been less clear. While some double-blind studies using garcinia cambogia and a placebo showed the HCA group as doubling or tripling weight loss over a 12-week period as compared to the control group, other studies showed a less promising result.
The Journal of the American Medical Association (JAMA) published such a study that used a daily dose of 1500mg of HCA over a 12-week period on healthy, overweight adults. At the end of the study, the group receiving garcinia cambogia did not see statistically different weight loss from the control group. However, this study has been criticized by some, with the claim that the high-fiber diet used in the trial likely interfered with the body’s ability to absorb HCA. Unfortunately, the study did not test the subjects to see whether HCA was found in the cells where it becomes active.
Garcinia cambogia reportedly does not have any known adverse effects in healthy adults, but there are some people who are advised not to take it. According to experts, this includes children, pregnant and lactating women, those diagnosed with diabetes mellitus, and people with Alzheimer’s or other forms of dementia disease. In the case of Alzheimer’s patients, it is thought HCA might form acetylcholine in the brain, while diabetics could be affected by HCA’s tendency to lower blood sugar. Conversely, in healthy adults this latter effect can purportedly curb cravings for sweets and carbohydrates.
Garcinia cambogia is usually sold in capsule form, standardized to include a percentage of HCA, the active ingredient. Only brands standardized to 50% or greater HCA are generally recommended. For maximum effect, the daily dose is divided in three parts, taking one or more capsules 30-60 minutes before breakfast, lunch, and dinner.
Some manufacturers claim garcinia cambogia must build up in the system before the full benefits can be realized. It has also been suggested that HCA might help people who have already attained their ideal weight to maintain it. The Food and Drug Administration (FDA) does not regulate garcinia cambogia. People who are considering augmenting a healthy diet and exercise regimen with herbal aids like HCA should see their physicians for personalized advice.
GUARANA
Studies involving guaraná show benefits to cognitive function. They have not been evaluated by the Food and Drug Administration (FDA) or similar government agencies. In the United States, guaraná holds a GRAS-status, i.e. generally regarded as safe and must be labeled as not intended to diagnose, treat, cure or prevent any disease.
The Journal of Human Nutrition and Dietetics published a study in June 2001 showing an average 11.2 pound weight loss in a group taking a mixture of yerba mate, guaraná and damiana, compared to an average 1 pound loss in a placebo group after 45 days.
A university study in Brazil of guaraná extract showed a platelet aggregation decrease of up to 37% of control values and a decrease of platelet thromboxane formation from arachidonic acid of up to 78% of control values. This study may be significant to stroke and heart attack risk reduction because when excess thromboxane formation occurs, an arterial blood clot can develop, resulting in a heart attack or ischemic stroke
A separate 1997 study of guaraná's effects on the physical activity of rats showed increased memory retention and physical endurance when compared with a placebo.
Other studies have shown antioxidant, antibacterial, and fat cell reduction (when combined with conjugated linoleic acid) properties in guaraná Although side-effects of guaraná are rare, drugs.com recommends, "When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous". Drugs.com also advises not to mix guaraná with ephedrine.
The Journal of Human Nutrition and Dietetics published a study in June 2001 showing an average 11.2 pound weight loss in a group taking a mixture of yerba mate, guaraná and damiana, compared to an average 1 pound loss in a placebo group after 45 days.
A university study in Brazil of guaraná extract showed a platelet aggregation decrease of up to 37% of control values and a decrease of platelet thromboxane formation from arachidonic acid of up to 78% of control values. This study may be significant to stroke and heart attack risk reduction because when excess thromboxane formation occurs, an arterial blood clot can develop, resulting in a heart attack or ischemic stroke
A separate 1997 study of guaraná's effects on the physical activity of rats showed increased memory retention and physical endurance when compared with a placebo.
Other studies have shown antioxidant, antibacterial, and fat cell reduction (when combined with conjugated linoleic acid) properties in guaraná Although side-effects of guaraná are rare, drugs.com recommends, "When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous". Drugs.com also advises not to mix guaraná with ephedrine.
FUCUS VESICULOSUS
Common food in Japan, it is used as an additive and flavoring in various food products in Europe. Bladder wrack is commonly found as a component of kelp tablets or powders used as nutritional supplements. It is sometimes loosely called kelp, but that term technically refers to a different seaweed.
Close-up of bladder wrack's eponymous vesicles
Primary chemical constituents of this plant include mucilage, algin, mannitol, beta-carotene, zeaxanthin, iodine, bromine, potassium, volatile oils, and many other minerals. The main use of bladder wrack (and other types of seaweed) in herbal medicine is as a source of iodine, an essential nutrient for the thyroid gland. Bladder wrack has proved most useful in the treatment of underactive thyroid glands (hypothyroidism) and goitre. Through the regulation of thyroid function, there is an improvement in all the associated symptoms. Where obesity is associated with thyroid trouble, this herb may be very helpful in reducing the excess weight. It has a reputation in helping the relief of rheumatism and rheumatoid arthritis, both used internally and as an external application upon inflamed joints. A chemical constituent of bladder wrack called alginic acid swells upon contact with water; when taken orally, it forms a type of "seal" at the top of the stomach, and for this reason is used in several over-the-counter preparations for heartburn. The same constituent gives bladder wrack laxative properties as well. Other proposed uses of bladder wrack include treating atherosclerosis and strengthening immunity, although there is no scientific evidence at present that it works for these purposes.
Bladder wrack should not be used in cases of hyperthyroidism or cardiac problems, or during pregnancy and lactation. Excessive dosage (many times the recommended dosage) may lead to hyperthyroidism, tremor, increased pulse rate and elevated blood pressure
Close-up of bladder wrack's eponymous vesicles
Primary chemical constituents of this plant include mucilage, algin, mannitol, beta-carotene, zeaxanthin, iodine, bromine, potassium, volatile oils, and many other minerals. The main use of bladder wrack (and other types of seaweed) in herbal medicine is as a source of iodine, an essential nutrient for the thyroid gland. Bladder wrack has proved most useful in the treatment of underactive thyroid glands (hypothyroidism) and goitre. Through the regulation of thyroid function, there is an improvement in all the associated symptoms. Where obesity is associated with thyroid trouble, this herb may be very helpful in reducing the excess weight. It has a reputation in helping the relief of rheumatism and rheumatoid arthritis, both used internally and as an external application upon inflamed joints. A chemical constituent of bladder wrack called alginic acid swells upon contact with water; when taken orally, it forms a type of "seal" at the top of the stomach, and for this reason is used in several over-the-counter preparations for heartburn. The same constituent gives bladder wrack laxative properties as well. Other proposed uses of bladder wrack include treating atherosclerosis and strengthening immunity, although there is no scientific evidence at present that it works for these purposes.
Bladder wrack should not be used in cases of hyperthyroidism or cardiac problems, or during pregnancy and lactation. Excessive dosage (many times the recommended dosage) may lead to hyperthyroidism, tremor, increased pulse rate and elevated blood pressure
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